Treatment of murine disseminated candidiasis with L-743,872.

نویسندگان

  • J R Graybill
  • L K Najvar
  • M F Luther
  • A W Fothergill
چکیده

L-743,872 (M991), which is a pneumocandin derivative, was evaluated in a mouse model of disseminated candidiasis caused by a fluconazole-resistant isolate of Candida albicans. In immunocompetent mice M991 prolonged survival at doses as low as 0.0125 mg/kg of body weight per day. In neutropenic mice 0.05 mg/kg was the lowest effective dose. M991 is a very potent drug for treatment of disseminated candidiasis.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 41 8  شماره 

صفحات  -

تاریخ انتشار 1997